This executive order recites that the implementation of the administration’s prior directions regarding childhood vaccines has been delayed due to litigation over the composition of the Advisory Committee on Immunization Practices. Therefore, this executive order reaffirms that it is the policy of the United States that the core childhood vaccine recommendations should be aligned with scientific evidence and best practices from peer developed countries while preserving access to vaccines currently available to Americans. The order recommends (a) immunizations for all children, including measles, mumps, rubella, diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type B, pneumococcal disease, human papillomavirus and varicella; (b) immunizations recommended for certain high-risk groups or populations; and (c) immunizations based on shared clinical decision-making, such as hepatitis A, hepatitis B, rotavirus, meningococcal disease, influenza and COVID-19. States and territories are advised to review these recommendations and consider updating relevant laws and regulations that define the scope of immunization requirements. The order directs the secretary of health and human services to offer options to administer core childhood vaccines; assess the ideal time and sequencing of such vaccines; develop additional alternative adjuvants to aluminum; and ensure continuous evaluation of the risk-benefit profiles of all childhood vaccines. The order also directs the attorney general to take appropriate measures to further meritorious legal actions challenging state laws that conflict with states’ constitutional and federal statutory obligations related to parental authority, religious freedom, disability accommodations and equal protection under the law with respect to childhood immunizations.